Quick answer: This healthy tuna sandwich has about 27 grams of protein at just 265 calories, and takes 15 minutes with no cooking. It’s open-face — one slice of bread, not two — with a light Greek yogurt binder, avocado, and a genuinely large pile of vegetables. Serves 4. Sodium is comparatively low, about 435 mg per serving.
Where High Protein Tuna Sandwich maximizes protein with a full two-slice sandwich and both dairy sources, this one goes the other direction — lighter, open-face, and built around vegetables doing most of the volume instead of bread and dairy.
Why This Recipe Has About 27 Grams of Protein
| Source | Per serving |
| Canned tuna, drained (110 g) | 21.3 g |
| Plain Greek yogurt (15 g) | 1.5 g |
| Whole grain bread, 1 slice (35 g) | 3.2 g |
| Avocado (30 g) | 0.6 g |
| Total | 26.6 g |
A single slice of bread and a small amount of yogurt, rather than a full sandwich’s worth — the tuna itself carries most of the protein.
A Note on Sodium
About 435 mg per serving, roughly 19% of the WHO’s 2,300 mg daily limit — meaningfully lower than the high-protein version, since there’s half the bread and no cottage cheese.
What You Need
Makes 4 open-face sandwiches
- 4 cans (5 oz / 142 g each) light tuna in water, drained (about 440 g drained total)
- ¼ cup (60 g) plain Greek yogurt
- 4 slices whole grain bread
- 1 avocado, sliced
- 1 cup cherry tomatoes, halved
- 1 cup cucumber, sliced
- Sprouts or microgreens, to serve

How to Make It
- Combine the tuna and Greek yogurt lightly — this is meant to be a thin binder, not a thick spread.
- Toast the bread, if desired.
- Layer tuna, avocado, tomatoes and cucumber on each slice.
- Top with sprouts and serve open-face.
Tips
Don’t overload the yogurt. The point of this version is that the vegetables and tuna itself provide the flavor, not a heavy dressing.
Slice the avocado just before serving so it doesn’t brown while the sandwich sits.
Substitutions
Bread: any open-face-friendly bread works — a hearty rye or sourdough holds up particularly well.
Storage
Assemble fresh. The tuna mixture keeps 3 days refrigerated on its own.

Healthy Tuna Sandwich
Ingredients
Method
- Combine tuna and yogurt lightly.
- Toast the bread if desired.
- Layer tuna, avocado, tomatoes and cucumber on each slice.
- Top with sprouts and serve open-face.
Notes
- Lower in both calories and sodium than the high-protein version.
- Assemble just before eating.
Nutrition
Per serving (recipe makes 4):
| Calories | 265 |
| Protein | 27 g |
| Sodium | 435 mg |
Preliminary calculation from USDA FoodData Central reference values, not yet verified against a finished Tuna nutrition workbook.
Frequently Asked Questions
How is this different from High Protein Tuna Sandwich?
That one uses two slices of bread and both Greek yogurt and cottage cheese for a higher protein total. This one is open-face with one slice, built to be lighter across both calories and sodium.
Can I make it a closed sandwich instead?
Yes, with a second slice of bread — it raises both the calorie and sodium totals somewhat.
What bread works best open-face?
A sturdier bread — rye or sourdough — holds the toppings better than a very soft sandwich bread.
Can I meal prep this?
Keep the tuna mixture separate from the bread and vegetables, and assemble fresh each time.
More High Protein Tuna Recipes
Part of the 🌯 Tuna Wraps collection, alongside High Protein Tuna Sandwich.
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